Category Archives: Health

How Clay Siegall changed the way cancer is treated

In 2011, Seattle Genetics, the company that Dr. Clay Siegall founded in 1998, was granted FDA approval for its first drug, Adcetris. This drug, generic name brentuximab vedotin, was a revolutionary new kind of cancer treatment called an antibody drug conjugate. Over the next five years, Adcetris would prove itself under real-world treatment scenarios, changing the way cancer is fought and driving more resources into the research and development of antibody drug conjugates for all types of malignancies.



Tinkering with the gears of nature


Dr. Siegall was always interested in ways to reduce the pain and suffering of existing cancer treatments. In college, he became aware of the barbarity of many of the reigning treatment modalities for cancer, such as radiation, chemotherapy and surgery, often radical and involving the complete amputation of body parts.


Almost all of these treatments left patients with permanent deficits, at best, and permanent disabilities, at worst. Over his time as a senior researcher at Bristol-Meyers-Squibb, Dr. Siegall helped discover and develop a new class of drugs called antibody drug conjugates that eliminated the systemic side effects of chemotherapy and radiation and promised to obviate the need for radical surgery. The drugs operated by delivering the anti-cancer chemical directly to the tumor. With an enzyme or antibody acting as a sort of lock to which only the cancer cells hold the key, the cytotoxin, or cell killing drug, can only be released in the direct presence of the tumor cells. While, in principle, this is conceptually simple, it is far easier said than done.


In 1998, Dr. Siegall founded his own company, Seattle Genetics. It quickly began developing the practical biologic means by which to deliver the cytotoxins directly to the tumor site. In one ingenious patented process, Seattle Genetics developed a system by which mice are injected with tumor-specific proteins. The mice’s bodies then produce tumor antigens. These antigens are not generally effective in suppressing the aggressive tumor, but they do contain the genetic key pattern to attach to that tumor type. Seattle Genetics then engineers a similar molecule and attaches the cytotoxin to it. The molecule goes hunting for the specific tumor cells and, when it finds them, releases the cytotoxin.

The Beauty Of Beneful

The dog food industry is a multi-billion dollar industry. There are many dog food brands out there on the market and it can be difficult to find the right one that will provide the right nutrition for a dog. These days, many dog owners are looking for a healthier alternative to the dog food that they currently give their pets. Before, many dog owners would only look at the brand of food and not the ingredients but the majority of dog owners are making conscious decisions about the food they give their furry loved ones by reading ingredients before they purchase the food and researching how dog food brands make their dog food.

There are more and more healthy dog food options out there. Many healthy dog food brands are making high-quality dog food that is meant to provide flavor and nutrition to dogs of all breeds. The healthy dog food that is available right now has ingredients that even humans can consume. In many of these dog foods, you will find quality meats, fresh vegetables and fresh fruits. Grains are steadily being eliminated from the ingredient list of many dog foods. There are two types of dog food that are available, dry dog food and wet dog food. The wet dog food from healthy dog brands have more fresh ingredients, which is ideal for all dogs.

Dog owners that want to change the food that they give their dogs can look for a few things when they make that decision. Dog owners should find brands that promote healthy nutrition for dogs of all breeds. They should also find dog food brands that conduct quality control on all of their products. The most important aspect of finding the right food is researching and reading the ingredients. The ingredients in dog food is vital because it is what is going into the dog.

Beneful is a high-quality dog food brand that is a part of the Nestle Purina Petcare brand. Beneful provides dry dog food, wet dog food and dog snacks. Beneful’s wet food is made with quality chicken, beef, pork and lamb. The dog food also includes fresh carrots, barley and green beans. Dogs can enjoy Beneful in small dry bits or in mid-sized wet chunks. Beneful has dry dog snacks that include bacon, beef and cheese. These snacks are made into crackers and shortbread cookies.